[2,2']bipyridinyl; potassium fluoride; acetic acid; palladium diacetate in tetrahydrofuran T=80°C; 48 h;

1: meta-difluorobenzene With TMP2Mg*2LiCl; zinc(II) chloride in tetrahydrofuran T=25°C; 12 h; Inert atmosphere; 2: benzoyl chloride With copper (I) cyanide in tetrahydrofuran T=-40 - 25°C; Negishi cross-coupling reaction; Inert atmosphere;

palladium diacetate; caesium carbonate; triphenylphosphine in o-xylene T=150°C; 16 h; Inert atmosphere;