2-(4-氟苄基)丙二酸二乙酯合成路线 （共 7 条）
反应条件
1: sodium chloride / dimethyl sulfoxide 2: diisobutylaluminium hydride 3: carbon tetrabromide; triphenylphosphine View Scheme
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883
反应条件
1,4-diaza-bicyclo[2.2.2]octane; tris(2,4,6-trifluorophenyl)borane
T=50°C; P=3750.38 Torr; 24 h; Inert atmosphere;
参考文献
Nicasio, Juan A.; Steinberg, Sebastian; Ines, Blanca; Alcarazo, Manuel
Chemistry - A European Journal, 2013 , vol. 19, # 33 p. 11016 - 11020
反应条件
1: diethyl malonate With sodium ethanolate in ethanol
T=20°C;
2: 4-bromomethyl-fluorobenzene in ethanol
Reflux;
参考文献
Yip, Kai-Tai; Yang, Dan
Organic Letters, 2011 , vol. 13, # 8 p. 2134 - 2137
反应条件
ethanol; sodium
1 h; Heating;
参考文献
Boehme, Thomas M.; Keim, Christine; Kreutzmann, Kai; Linder, Matthias; Dingermann, Theo; Dannhardt, Gerd; Mutschler, Ernst; Lambrecht, Guenter
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 856 - 867
参考文献
Citterio, Attilio; Sebastiano, Roberto; Marion, Antonio; Santi, Roberto
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5328 - 5335
反应条件
1: sodium chloride / dimethyl sulfoxide
2: diisobutylaluminium hydride
View Scheme
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883
反应条件
sodium chloride in dimethyl sulfoxide
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883
