1-(4-甲氧基苯基)-1,2,3,4-四氢异喹啉合成路线 （共 6 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol
P=2792.6 Torr; 10 h; Yield given;
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
1: With sodium hydroxide; ethanol; water
T=100°C; 3 h;
2: With potassium hydroxide; ethanol; water
64 h; Heating / reflux;
参考文献
AMGEN INC.
Patent: WO2009/73203 A1, 2009 ;
Location in patent: Page/Page column 111-112 ;
WO 2009/073203 A1
反应条件
1: POCl3, P2O5 / 2 h / Heating
2: H2 / PtO2 / ethanol / 10 h / 2792.6 Torr
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
1: 87 percent / CH2Cl2 / 4 h / Ambient temperature
2: POCl3, P2O5 / 2 h / Heating
3: H2 / PtO2 / ethanol / 10 h / 2792.6 Torr
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
1: 87 percent / CH2Cl2 / 4 h / Ambient temperature
2: POCl3, P2O5 / 2 h / Heating
3: H2 / PtO2 / ethanol / 10 h / 2792.6 Torr
View Scheme
参考文献
Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248
反应条件
Ersorb-4a in ethanol
T=80°C; Pictet-Spengler cyclisation; 20 h;
参考文献
Hegedues, Adrienn; Hell, Zoltan
Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8553 - 8555
