6-氯-5-硝基烟酸甲酯合成路线 （共 11 条）
反应条件
1: 5-nitro-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid With thionyl chloride; N,N-dimethyl-formamide 8 h; Reflux; 2: methanol in dichloromethane T=-40 - -30°C; 3: With sodium hydrogencarbonate in dichloromethane; water T=-30 - 20°C;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; OALMANN, Christopher; DISCH, Jeremy, S.; NG, Pui, Yee; PERNI, Robert, B.
Patent: WO2010/71853 A1, 2010 ;
Location in patent: Page/Page column 68 ;
反应条件
1: 5-nitro-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid With phosphorus pentachloride; trichlorophosphate T=100°C; 2 h; 2: methanol in diethyl ether T=0°C; 0.166667 h;
参考文献
WO2005/21544 A2, ;
Page/Page column 29 ;
WO 2005/021544 A2
反应条件
1: in methanol; hexane; dichloromethane T=0°C; 2: With trifluoroacetic acid in methanol; hexane; dichloromethane
参考文献
WO2010/51245 A1, ;
Page/Page column 34 ;
WO 2010/051245 A1
反应条件
in dichloromethane T=0°C;
参考文献
WO2005/77947 A1, ;
Page/Page column 17 ;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 19 p. 5374 - 5378
反应条件
ammonia in methanol T=0°C; 2 h;
参考文献
Zimmermann, Peter Jan; Buhr, Wilm; Brehm, Christof; Palmer, Andreas Marc; Feth, Martin Philipp; Senn-Bilfinger, Joerg; Simon, Wolfgang-Alexander
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 19 p. 5374 - 5378
反应条件
iron; ammonium chloride in methanol T=75°C; 2 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; OALMANN, Christopher; DISCH, Jeremy, S.; NG, Pui, Yee; PERNI, Robert, B.
Patent: WO2010/71853 A1, 2010 ;
Location in patent: Page/Page column 68 ;
反应条件
hydrogenchloride in ethanol; water
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6087380 A1, 2000 ;
US 6087380 A
参考文献
Almirall, S.A.
Patent: EP2527344 A1, 2012 ;
Location in patent: Page/Page column 24 ;
EP 2527344 A1
反应条件
sodium methylate in methanol; water
参考文献
Aventis Pharma Limited
Patent: US6472412 B1, 2002 ;
