反应条件
Multi-step reaction with 7 steps 1.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 18 h / Inert atmosphere; Reflux2.1: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere3.1: dihydrogen peroxide; acetic acid / water / 24 h / 20 °C / Inert atmosphere4.1: acetic acid; benzylamine / Inert atmosphere; Reflux5.1: sodium dithionite / water; acetone / 1 h / 50 °C / Inert atmosphere6.1: sodium acetate / ethanol / 0.17 h / Inert atmosphere; Reflux6.2: 48 h / Inert atmosphere; Reflux7.1: water; sodium hydroxide / ethanol / Inert atmosphere
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276