1: 96 percent / DDQ / dioxane; H2O 2: 90 percent / sodium bicarbonate / methanol View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1732991', constants.ctx, '0')">N,N,N',N,-tetramethylethylenediamine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587191', constants.ctx, '0')">dihydrogen peroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587206', constants.ctx, '0')">sec.-butyllithium</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a> <br /> <br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '110354', constants.ctx, '0')">4-(N,N-dimethlyamino)pyridine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: TMEDA; sec-BuLi / 0.75 h / 20 &deg;C<br />1.2: trimethyl borate / 1 h / 20 &deg;C<br />1.3: acetic acid; aq. hydrogen peroxide / 0 - 20 &deg;C<br />2.1: 95 percent / Et₃N; DMAP / CH₂Cl₂ <br /> <br /> &nbsp;