三甲基膦酰基乙酸酯合成路线

参考文献

Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng
Patent: US2013/102595 A1, 2013 ;
Location in patent: Paragraph 0623; 0624 ;

5927-18-4三甲基膦酰基乙酸酯+

824-54-42-溴-4-甲基苯甲醛

66192-28-7

参考文献

Harmata, Michael; Hong, Xuechuan; Schreiner, Peter R.
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1290 - 1296

5470-96-2喹啉-2-甲醛+

5927-18-4三甲基膦酰基乙酸酯

81124-46-1

参考文献

TOPOTARGET UK LIMITED
Patent: WO2004/76386 A2, 2004 ;
Location in patent: Page 92 ;

872-85-54-吡啶甲醛+

5927-18-4三甲基膦酰基乙酸酯

81124-49-43-(4-吡啶)丙烯酸甲酯

参考文献

Tetsuhashi, Masashi; Ishikawa, Minoru; Hashimoto, Mariko; Hashimoto, Yuichi; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5323 - 5338

5927-18-4三甲基膦酰基乙酸酯+

15186-48-8(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛

81703-94-8(S)-(+)-3-(2,2-二甲基-1,3-二噁戊环-4-基)-顺-2-丙烯酸甲酯+

81703-93-7(S)-(+)-3-(2,2-二甲基-1,3-二噁戊环-4-基)-反-2-丙烯酸甲酯

参考文献

DAISO CO., LTD.
Patent: EP1669353 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;

5927-18-4三甲基膦酰基乙酸酯+

1707-77-3双丙酮-D-甘露糖醇

81703-93-7(S)-(+)-3-(2,2-二甲基-1,3-二噁戊环-4-基)-反-2-丙烯酸甲酯

参考文献

Domingos, Jorge L. De O.; Vilela, Guilherme V. M. De A.; Costa, Paulo R. R.; Dias, Ayres G.
Synthetic Communications, 2004 , vol. 34, # 4 p. 589 - 598

5927-18-4三甲基膦酰基乙酸酯+

102355-63-5

81703-93-7(S)-(+)-3-(2,2-二甲基-1,3-二噁戊环-4-基)-反-2-丙烯酸甲酯

参考文献

Pichlmair, Stefan; de Lera Ruiz, Manuel; Basu, Kallol; Paquette, Leo A.
Tetrahedron, 2006 , vol. 62, # 22 p. 5178 - 5194

5927-18-4三甲基膦酰基乙酸酯+

15186-48-8(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛

81703-94-8(S)-(+)-3-(2,2-二甲基-1,3-二噁戊环-4-基)-顺-2-丙烯酸甲酯+

81703-93-7(S)-(+)-3-(2,2-二甲基-1,3-二噁戊环-4-基)-反-2-丙烯酸甲酯

参考文献

DAISO CO., LTD.
Patent: EP1669353 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;

5927-18-4三甲基膦酰基乙酸酯+

532-24-1

82482-72-2

参考文献

GLAXO GROUP LIMITED
Patent: WO2007/16650 A2, 2007 ;
Location in patent: Page/Page column 8; 9 ;
WO 2007/016650 A2

532-24-1+

5927-18-4三甲基膦酰基乙酸酯

82482-72-2

参考文献

Laine, Dramane I.; Wan, Zehong; Yan, Hongxing; Zhu, Chongjie; Xie, Haibo; Fu, Wei; Busch-Petersen, Jakob; Neipp, Christopher; Davis, Roderick; Widdowson, Katherine L.; Blaney, Frank E.; Foley, James; Bacon, Alicia M.; Webb, Edward F.; Luttmann, Mark A.; Burman, Miriam; Sarau, Henry M.; Salmon, Michael; Palovich, Michael R.; Belmonte, Kristen
Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5241 - 5252