2-[(乙酰氧基)甲氧基]乙基乙酸酯合成路线 （共 38 条）
反应条件
sulfuric acid Ambient temperature;
参考文献
Rosowsky; Kim; Wick
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1177 - 1181
反应条件
sodium acetate in acetic acid T=110°C; 1 h;
参考文献
Matsumoto; Kaneko; Yamada; Takeuchi; Mori; Mizuno
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 3 p. 1153 - 1157
反应条件
1: 1,3-dioxacyclopentane; acetyl-bromide 2: sodium acetate With acetic acid T=110°C; 1 h;
参考文献
Friedrichsen, Gerda Marie; Chen, Weiqing; Begtrup, Mikael; Lee, Chao-Pin; Smith, Philip L.; Borchardt, Ronald T.
European Journal of Pharmaceutical Sciences, 2002 , vol. 16, # 1-2 p. 1 - 13
反应条件
in N,N-dimethyl-formamide
参考文献
Journal of the American Chemical Society, , vol. 68, p. 735
反应条件
tin(IV) chloride in acetonitrile 48 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Keppler; De Clercq
Archiv der Pharmazie, 1987 , vol. 320, # 3 p. 271 - 274
反应条件
sodium hydroxide; toluene-4-sulfonic acid 1.) 100 deg C, 20 h, 2.) room temperature, overnight; Yield given. Multistep reaction;
参考文献
Shiragami; Koguchi; Tanaka; Takamatsu; Uchida; Ineyama; Izawa
Nucleosides and Nucleotides, 1995 , vol. 14, # 3-5 p. 337 - 340
反应条件
in methanol; dichloromethane
参考文献
LUPIN LABORATORIES LIMITED
Patent: EP806425 A1, 1997 ;
反应条件
in methanol; toluene
参考文献
LUPIN LABORATORIES LIMITED
Patent: EP806425 A1, 1997 ;
反应条件
1: 2-N-Acetylguanine; 1,1,1,3,3,3-hexamethyl-disilazane With ammonium sulfate 2 h; Heating; 2: 2-acetoxyethyl acetoxymethyl ether With iodine-doped natural phosphate in acetonitrile Heating; Further stages.;
参考文献
Lazrek, Hassan B.; Baddi, Laila; Smietana, Michael; Vasseur, Jean-Jacques; Sebti, Said; Zahouily, Mohamed
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 10-11 p. 1107 - 1112
