Boc-L-谷氨酸5苄酯Alpha甲酯合成路线 （共 13 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
REMPEX PHARMACEUTICALS, INC.; GLINKA, Tomasz; HIGUCHI, Robert; HECKER, Scott; EASTMAN, Brian; RODNY, Olga
Patent: WO2012/109164 A1, 2012 ;
Location in patent: Page/Page column 39 ;
WO 2012/109164 A1
反应条件
1: 4(S)-carboxy-4-(N-t-butoxycarbonylamino)butanoic acid benzyl ester With potassium carbonate in acetone 0.166667 h; Inert atmosphere; 2: dimethyl sulfate in acetone T=20°C; 1 h; Inert atmosphere;
参考文献
Chakraborty, Subrata; Tai, Dar-Fu
Tetrahedron Letters, 2014 , vol. 55, # 14 p. 2274 - 2276
反应条件
triethylamine; isobutyl chloroformate
参考文献
Nouvet, Andre; Lamaty, Frederic; Lazaro, Rene
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2099 - 2102
反应条件
in diethyl ether; ethanol T=65°C; 0.333333 h;
参考文献
Boudreault, Pierre-Luc; Voyer, Normand
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1459 - 1465
反应条件
1: DCC / CH2Cl2 / 0.5 h / 0 °C 2: 2.1 g / CH2Cl2 / 16 h View Scheme
参考文献
Chemical Communications, , # 37 p. 4652 - 4654
反应条件
1.1: H2SO4 1.2: pyridine / ethanol 2.1: triethylamine / dimethylformamide 3.1: potassium carbonate / dimethylformamide View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 12 p. 1915 - 1923
反应条件
1: triethylamine / dimethylformamide 2: potassium carbonate / dimethylformamide View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 12 p. 1915 - 1923
反应条件
1.1: H2SO4 1.2: pyridine / ethanol 2.1: triethylamine / dimethylformamide 3.1: potassium carbonate / dimethylformamide View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 12 p. 1915 - 1923
反应条件
in dichloromethane 16 h;
参考文献
Biron, Eric; Voyer, Normand
Chemical Communications, 2005 , # 37 p. 4652 - 4654
反应条件
in methanol; benzene
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1921 - 1924
