Boc-L-谷氨酸5苄酯Alpha甲酯合成路线 （共 13 条）
反应条件
palladium dihydroxide; hydrogen in ethanol
参考文献
Tetrahedron Letters, , vol. 39, # 15 p. 2099 - 2102
反应条件
1: H2 / Pd/C / tetrahydrofuran
2: 78 percent / EDC, DMAP / acetonitrile / Ambient temperature
3: 75 percent / Et3SiH / Pd/C / acetone / 2 h / Ambient temperature
View Scheme
参考文献
Tamura, Susan Y.; Goldman, Erick A.; Brunck, Terence K.; Ripka, William C.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 331 - 336
反应条件
1.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 83 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 100 percent / H2 / Pd/C / methanol / 12 h / 20 °C
3.1: 80 percent / DCC / CH2Cl2 / 12 h / -20 °C
4.1: 34 percent / 132 h / -196 °C
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
