N-叔丁氧羰基-L-谷氨酸二甲酯合成路线 （共 26 条）
参考文献
Varala, Ravi; Nuvula, Sreelatha; Adapa, Srinivas R.
Journal of Organic Chemistry, 2006 , vol. 71, # 21 p. 8283 - 8286
反应条件
1: [14C]-L-Glutamic acid With thionyl chloride in methanol T=20°C; 10 h; RefluxInert atmosphere; 2: di-tert-butyl dicarbonate With triethylamine in tetrahydrofuran T=0 - 20°C; 8 h; Inert atmosphere;
参考文献
Goswami, Koushik; Paul, Sibasish; Bugde, Sandesh T.; Sinha, Surajit
Tetrahedron, 2012 , vol. 68, # 1 p. 280 - 286
反应条件
1: methanol; [14C]-L-Glutamic acid With chloro-trimethyl-silane T=0 - 20°C; 2: di-tert-butyl dicarbonate With triethylamine in methanol T=20°C; 48 h;
参考文献
Arda, Ana; Soengas, Raquel G.; Nieto, M. Isabel; Jimenez, Carlos; Rodriguez, Jaime
Organic Letters, 2008 , vol. 10, # 11 p. 2175 - 2178
反应条件
lithium bromide in acetonitrile T=65°C; 10 h;
参考文献
Hernandez, J. Nicolas; Ramirez, Miguel A.; Martin, Victor S.
Journal of Organic Chemistry, 2003 , vol. 68, # 3 p. 743 - 746
反应条件
triethylamine in chloroform T=20°C; 16 h;
参考文献
Chen, Zhi-hong; He, Yong-bing; Hu, Chen-Guang; Huang, Xiao-huan
Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2051 - 2057
反应条件
1: TMSCl / 15 h / 20 °C 2: 88.0 g / Et3N / methanol / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 16 p. 4971 - 4980
参考文献
Pfizer Inc.
Patent: US2003/191107 A1, 2003 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide 120 h;
参考文献
Mou, Ke; Xu, Bo; Ma, Chao; Yang, Xiaoming; Zou, Xiaomin; Lue, Yang; Xu, Ping
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 2198 - 2202
反应条件
lithium bromide in acetonitrile T=65°C; 10 h;
参考文献
Journal of Organic Chemistry, , vol. 68, # 3 p. 743 - 746
反应条件
triethylamine in methanol Inert atmosphere;
参考文献
Organic Letters, , vol. 15, # 22 p. 5670 - 5673
