反应条件
1: 1.) LiNH2, liquid NH3 / 1.) -33 deg C, 2 h, 2.) THF, -33 deg C, 0.5 h 2: 90 percent / NaNH2, 1,3-diaminopropane / 2.5 h / 80 °C 3: 96 percent / PTS / CHCl3 / 6 h / Ambient temperature 4: 1.) LiNH2, liquid NH3 / 1.) -33 deg C, 2 h, 2.) THF, -33 deg C, 0.5 h 5: H2 / Pd/C / ethyl acetate / 12 h 6: conc. HCl / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 14, # 8 p. 779 - 786
