1: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 24 h; 2: With sodium hydrogencarbonate in water; N,N-dimethyl-formamide
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/48771 A1, 2007 ;
Location in patent: Page/Page column 51 ;
WO 2007/048771 A1
sodium hydroxide in dichloromethane; water T=20 - 35°C; 2 h; Inert atmosphere;
参考文献
Connolly, Terrence J.; Constantinescu, Anton; Lane, Tim S.; Matchett, Michael; McGarry, Patrick; Paperna, Mariya
Organic Process Research and Development, 2005 , vol. 9, # 6 p. 837 - 842