4-硝基吡咯-2-羧酸乙酯合成路线 （共 18 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; Ambient temperature;
参考文献
SCHERING CORPORATION
Patent: WO2008/79293 A1, 2008 ;
Location in patent: Page/Page column 73 ;
反应条件
1: ethanol; sodium methylate 2: ethanol; aqueous NaOH View Scheme
参考文献
Weiss et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1266
Full Text View citing articles Show Details
Am. Cyanamid Co.
Patent: US2785181 , 1954 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 20 °C 2.1: ammonia / methanol / -10 - 80 °C / Sealed tube 3.1: pyridine / 1,4-dioxane / 1 h / Reflux View Scheme
参考文献
AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; BHAGWAT, Shripad, S.; HADD, Michael, J.; HOLLADAY, Mark, W.; LIU, Gang; MILANOV, Zdravko, V.; PATEL, Hitesh, K.; SETTI, Eduardo; SINDAC, Janice, A.
Patent: WO2011/88045 A1, 2011 ;
WO 2011/088045 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 20 °C 2.1: ammonia / methanol / -10 - 80 °C / Sealed tube 3.1: pyridine / 1,4-dioxane / 1 h / Reflux 4.1: triethylamine; trichlorophosphate / Inert atmosphere; Reflux View Scheme
参考文献
AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; BHAGWAT, Shripad, S.; HADD, Michael, J.; HOLLADAY, Mark, W.; LIU, Gang; MILANOV, Zdravko, V.; PATEL, Hitesh, K.; SETTI, Eduardo; SINDAC, Janice, A.
Patent: WO2011/88045 A1, 2011 ;
WO 2011/088045 A1
反应条件
potassium carbonate in acetone
2 h; Heating;
参考文献
Bremer, Ryan E.; Wurtz, Nicholas R.; Szewczyk, Jason W.; Dervan, Peter B.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2093 - 2103
反应条件
1: ethanol; sodium methylate
2: ethanol; aqueous NaOH
3: palladium/charcoal; ethanol / Hydrogenation
View Scheme
参考文献
Am. Cyanamid Co.
Patent: US2785181 , 1954 ;
反应条件
CH3I; sodium ethanolate in ethanol
参考文献
Zhang, Wentao; Liehr, Sebastian Johannes Reinhard; Velligan, Mark Douglas; Dyatkina, Natalia B.; Botyanszki, Janos; Shi, Dong-Fang; Roberts, Christopher Don; Khorlin, Alexander; Nelson, Peter Harold; Muchowski, Joseph Martin
Patent: US2002/37856 A1, 2002 ;
反应条件
1: ethanol; sodium methylate
2: palladium/charcoal; ethanol / Hydrogenation
View Scheme
参考文献
Weiss et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1266
Full Text View citing articles Show Details
Am. Cyanamid Co.
Patent: US2785181 , 1954 ;
