1,4,5,6-四氢-3-环戊二烯并吡唑羧基酸乙酯合成路线 (共 10 条)
反应条件
1: With potassium ethanolate in ethanol T=29°C; 2: With hydrogenchloride; hydrazine hydrate in ethanol T=2 - 10°C;
参考文献
Wilson, Robert D.; Cleator, Ed; Ashwood, Michael S.; Bio, Matthew M.; Brands, Karel M.J.; Davies, Antony J.; Dolling, Ulf-H; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; McKeown, Arlene E.; Oliver, Steven F.; Reamer, Robert A.; Sheen, Faye J.; Stewart, Gavin W.; Zhou, George X.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 543 - 547
反应条件
hydrazine hydrate; acetic acid T=0°C; Reflux;
参考文献
Wu, Deyan; Jin, Fangfang; Lu, Weiqiang; Zhu, Jin; Li, Cui; Wang, Wei; Tang, Yun; Jiang, Hualiang; Huang, Jin; Liu, Guixia; Li, Jian
Chemical Biology and Drug Design, 2012 , vol. 79, # 6 p. 897 - 906
反应条件
hydrazine monohydrochloride in ethanol; water T=75°C; Product distribution / selectivity;
参考文献
WO2006/52569 A1, ;
Page/Page column 74 ;
反应条件
1: EtONa / ethanol / 18 h / 20 °C 2: N2H4*H2O; AcOH / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 18 p. 3945 - 3951
反应条件
ethanol; hydrazine anschliessendes Behandeln mit wss.NH3;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 536, p. 97,108
反应条件
potassium hydroxide in methanol; water T=43°C; 1.5 h;
参考文献
Wilson, Robert D.; Cleator, Ed; Ashwood, Michael S.; Bio, Matthew M.; Brands, Karel M.J.; Davies, Antony J.; Dolling, Ulf-H; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; McKeown, Arlene E.; Oliver, Steven F.; Reamer, Robert A.; Sheen, Faye J.; Stewart, Gavin W.; Zhou, George X.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 543 - 547
反应条件
ammonia in methanol T=95°C; 20 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2006/52569 A1, 2006 ;
Location in patent: Page/Page column 79 ;
反应条件
1: ethanolic KOH 2: copper-powder / unter Wasserstoff View Scheme
参考文献
v. Auwers; Noll
Justus Liebigs Annalen der Chemie, 1938 , vol. 536, p. 97,108
反应条件
hydrazine hydrate in ethanol 36 h; Reflux;
参考文献
Wu, Deyan; Jin, Fangfang; Lu, Weiqiang; Zhu, Jin; Li, Cui; Wang, Wei; Tang, Yun; Jiang, Hualiang; Huang, Jin; Liu, Guixia; Li, Jian
Chemical Biology and Drug Design, 2012 , vol. 79, # 6 p. 897 - 906
反应条件
1.1: ethanol; water / 168 h / 20 °C
1.2: 5 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 35 °C / Reflux
2.2: 2 h / Reflux
2.3: 6 h / Reflux
View Scheme
参考文献
Musatov; Starodubtseva; Rakishev; Turova; Vinogradov
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1199 - 1203