2-(2-硝基苯胺基)苯甲酸合成路线 （共 23 条）
反应条件
1: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C
2: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
3: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: dichloromethane / 1 h / 20 °C
2: nitric acid; acetic acid / 0.5 h / 0 °C
3: hydrogenchloride / water / 2 h / |Reflux
4: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; acetic acid / 0.5 h / 0 °C
2: hydrogenchloride / water / 2 h / |Reflux
3: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
3-methyl-1-butanol; anhydrous copper acetate; potassium carbonate
参考文献
Ullmann; Bader
Justus Liebigs Annalen der Chemie, 1907 , vol. 355, p. 327
参考文献
Linnell; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 2459
参考文献
Linnell; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 2459
反应条件
1: potassium acetate; absolute alcohol
2: tin (II)-chloride; hydrogen chloride; diethyl ether
3: thionyl chloride / Behandeln mit Aluminiumchlorid in Toluol
View Scheme
参考文献
Linnell; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 2459
参考文献
Nadaraj; Kalaivani; Selvi, S. Thamarai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 8 p. 1958 - 1960
反应条件
sulfuric acid
T=90°C; 0.166667 h; Microwave irradiation;
参考文献
Markovich; Kudryavtseva; Brylev; Koroleva
Russian Journal of General Chemistry, 2012 , vol. 82, # 1 p. 149 - 152
