3-氯磺酰基-2-噻吩甲酸甲酯合成路线 （共 23 条）
反应条件
phosphorus pentachloride in methanol; chloroform; trichlorophosphate
反应条件
in methanol; chloroform
参考文献
BASF Aktiengesellschaft
Patent: US4028373 A1, 1977 ;
反应条件
in chloroform 3 h; Heating;
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
hydrogenchloride; sulfur dioxide; copper dichloride; sodium nitrite 1.) -5 deg C; Multistep reaction;
参考文献
Pharmazie, , vol. 49, # 2-3 p. 115 - 117
反应条件
1: 210 g / 1.) sodium bisulfite, NaOH, CuCl, 2.) KCl / H2O / 16 h / 143 °C 2: POCl3, PCl5 / 1.5 h / Heating 3: 95 percent / CHCl3 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 4 p. 678 - 682
反应条件
ammonia in dichloromethane T=0°C; 2 h;
参考文献
Vega, Salvador; Madronero, Ramon; Diaz, J. Antonio; Junquera, Francisco; Alonso, Javier; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 329 - 334
反应条件
1: 81 percent / 98percent hydrazine hydrate, triethylamine / ethanol / 2 h / 0 °C 2: 86 percent / methanol / Heating View Scheme
参考文献
Vega; Diaz
Pharmazie, 1992 , vol. 47, # 10 p. 765 - 767
反应条件
1: 81 percent / 98percent hydrazine hydrate, triethylamine / ethanol / 2 h / 0 °C 2: 75 percent / methanol / Heating View Scheme
参考文献
Vega; Diaz
Pharmazie, 1992 , vol. 47, # 10 p. 765 - 767
反应条件
1: NaH / tetrahydrofuran / 1 h / Ambient temperature 2: aq. NaOH / 8 h / Ambient temperature View Scheme
参考文献
Eisai RandD Management Co., Ltd.; Tanaka, Keigo; Nishioka, Tomoki
Patent: US2013/197045 A1, 2013 ;
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C 1.2: 5 h / 0 - 20 °C 2.1: water; sodium hydroxide / methanol / 5 h / 20 °C 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C 3.2: 5 h / 20 °C View Scheme
参考文献
Eisai RandD Management Co., Ltd.; Tanaka, Keigo; Nishioka, Tomoki
Patent: US2013/197045 A1, 2013 ;
