3-氯磺酰基-2-噻吩甲酸甲酯合成路线 （共 23 条）
反应条件
sodium hydride 1.) THF, 10 min, 2.) THF, RT, 4 h; Multistep reaction;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/255036 A1, 2008 ;
Location in patent: Page/Page column 65-66 ;
US 20080255036 A1
反应条件
1: 71 percent / pyridine / 4 h / Ambient temperature 2: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating View Scheme
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
1: 71 percent / pyridine / 4 h / Ambient temperature 2: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h 4: 75 percent / xylene / 7 h / Heating View Scheme
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
1: 71 percent / pyridine / 4 h / Ambient temperature 2: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h View Scheme
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
pyridine 4 h; Ambient temperature;
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
1: 81 percent / 98percent hydrazine hydrate, triethylamine / ethanol / 2 h / 0 °C 2: 78 percent / methanol / Heating View Scheme
参考文献
Vega; Diaz
Pharmazie, 1992 , vol. 47, # 10 p. 765 - 767
反应条件
1: 88 percent / NH3 (gas) / CH2Cl2 / 2 h / 0 °C 2: 85 percent / 2M NaOMe / methanol / 24 h / Heating 3: 42 percent / PCl5 View Scheme
参考文献
Vega, Salvador; Madronero, Ramon; Diaz, J. Antonio; Junquera, Francisco; Alonso, Javier; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 329 - 334
反应条件
1: 88 percent / NH3 (gas) / CH2Cl2 / 2 h / 0 °C 2: 85 percent / 2M NaOMe / methanol / 24 h / Heating 3: 44 percent / PCl5 View Scheme
参考文献
Vega, Salvador; Madronero, Ramon; Diaz, J. Antonio; Junquera, Francisco; Alonso, Javier; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 329 - 334
反应条件
1: 88 percent / NH3 (gas) / CH2Cl2 / 2 h / 0 °C
2: 85 percent / 2M NaOMe / methanol / 24 h / Heating
3: 42 percent / PCl5
View Scheme
参考文献
Vega, Salvador; Madronero, Ramon; Diaz, J. Antonio; Junquera, Francisco; Alonso, Javier; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 329 - 334
反应条件
1.1: aq. NH3 / acetone / 1 h
2.1: NaNO2; aq. H2SO4; acetic acid / 0.17 h / 5 °C
2.2: 2 percent / NaNO2; CuCl / H2O / 0.17 h / 20 °C
View Scheme
参考文献
Bastide; Badon; Cambon; Vega
Pesticide Science, 1994 , vol. 40, # 4 p. 293 - 297
