2-(4-吡啶)-4-羟基-6-甲基嘧啶合成路线 （共 6 条）
反应条件
1: 100 percent / PhPOCl2 / 6 h / 150 - 170 °C
2: 97 percent / H2O; ethanol / 5 h / Heating
3: 57 percent / NaH / dimethylformamide / 2 h
View Scheme
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
trichlorophosphate in chloroform
参考文献
Sterling Drug Inc.
Patent: US4008235 A1, 1977 ;
反应条件
dichlorophenyl phosphine oxide
T=150 - 170°C; 6 h;
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
1: 100 percent / PhPOCl2 / 6 h / 150 - 170 °C
2: 31.2 g / NH2NH2*H2O / ethanol / 2 h / Heating
View Scheme
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
1: 100 percent / PhPOCl2 / 6 h / 150 - 170 °C
2: 31.2 g / NH2NH2*H2O / ethanol / 2 h / Heating
3: 22.6 g / H2 / Raney Ni / ethanol / 60 - 65 °C
View Scheme
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
1: 100 percent / PhPOCl2 / 6 h / 150 - 170 °C
2: 97 percent / H2O; ethanol / 5 h / Heating
View Scheme
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
