5-(2-萘基)-5-氧代戊酸合成路线 （共 6 条）
反应条件
1: 2-bromo-naphthalene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: glutaric acid anhydride in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Uyanik, Muhammet; Yasui, Takeshi; Ishihara, Kazuaki
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 14 p. 3848 - 3851
反应条件
potassium permanganate; 18-crown-6 ether in benzene 4 h; Ambient temperature;
参考文献
Utermoehlen, Clifford M.; Singh, Mahatam; Lehr, Roland E.
Journal of Organic Chemistry, 1987 , vol. 52, # 25 p. 5574 - 5582
反应条件
1: 1.) Mg, I2 / 1.) THF, 2 h, reflux, 2.) THF, RT, overnight 2: 86 percent / p-TsOH / benzene / 2 h / Heating 3: 56 percent / 18-crown-6 ether, KMnO4 / benzene / 4 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 25 p. 5574 - 5582
反应条件
1: 86 percent / p-TsOH / benzene / 2 h / Heating 2: 56 percent / 18-crown-6 ether, KMnO4 / benzene / 4 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 25 p. 5574 - 5582
反应条件
1: 1.) Mg, I2 / 1.) THF, 2 h, reflux, 2.) THF, RT, overnight 2: 86 percent / p-TsOH / benzene / 2 h / Heating 3: 56 percent / 18-crown-6 ether, KMnO4 / benzene / 4 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 25 p. 5574 - 5582
反应条件
sulfuric acid T=20°C;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 3647 - 3654
