5-碘-1-(2’,3’,5’-三-O-乙酰基-beta-D-呋喃核糖基)-咪唑并-4-甲腈合成路线 (共 4 条)
参考文献
Yamasa Shoyu Kabushiki Kaisha; Sumitomo Pharmaceuticals Company Limited
Patent: US5059590 A1, 1991 ;
反应条件
diiodomethane; isopentyl nitrite T=100°C; 0.5 h;
参考文献
Minakawa; Takeda; Sasaki; Matsuda; Ueda
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 778 - 786
反应条件
1: triethylamine, DMAP / acetonitrile / 0.5 h / Ambient temperature 2: 93 percent / pyridine, p-toluenesulfonyl chloride / 2 h / Ambient temperature 3: 70 percent / isoamyl nitrite, diiodomethane / 0.5 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 778 - 786
反应条件
1: 93 percent / pyridine, p-toluenesulfonyl chloride / 2 h / Ambient temperature 2: 70 percent / isoamyl nitrite, diiodomethane / 0.5 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 778 - 786