1-Boc-3-吡咯烷甲醛合成路线 （共 11 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.166667 h; 2: tert-butyl 3-(hydroxymethyl)-1-pyrrolidinecarboxylate in dichloromethane T=-78°C; 0.75 h; 3: With triethylamine in dichloromethane T=-78 - 20°C; 2 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/49605 A1, 2005 ;
Location in patent: Page/Page column 117; 118; 159 ;
反应条件
tris(2,4-di-tert-butyl-phenyl) phosphite; hydrogen; [rhodium(I)(carbonyl)2(acetylacetonate)] in toluene T=50°C; P=7500.75 Torr; 4 h; Product distribution; Further Variations:Reagents;
参考文献
Chemical Communications, , # 6 p. 694 - 695
反应条件
hydrogen; [rhodium(I)(carbonyl)2(acetylacetonate)]; tris(2,4-di-tert-butyl-phenyl) phosphite in toluene T=50°C; 4 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 12, # 26 p. 6930 - 6939
反应条件
hydrogen; [rhodium(I)(carbonyl)2(acetylacetonate)]; 2,4-dimethylphenyl-phosphabarrelene in toluene T=50°C; 4 h;
参考文献
Fuchs, Evelyn; Keller, Manfred; Breit, Bernhard
Chemistry - A European Journal, 2006 , vol. 12, # 26 p. 6930 - 6939
反应条件
1: CH2Cl2 / 1 h / 20 °C 2: tetrapropylammoniumperruthenate; NMO; 3 Angstroem molecular sieves / CH2Cl2 / 1 h View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 13 p. 1785 - 1789
反应条件
1: CH2Cl2 / 1 h / 20 °C 2: tetrapropylammoniumperruthenate; NMO; 3 Angstroem molecular sieves / CH2Cl2 / 1 h View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 13 p. 1785 - 1789
反应条件
potassium carbonate in methanol T=20°C; 2 h;
参考文献
WO2010/60952 A1, ;
Page/Page column 218 ;
WO 2010/060952 A1
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexanes T=0°C; 0.0833333 h; 2: 1-(t-butoxycarbonyl)-3-pyrrolidinecarboxaldehyde in tetrahydrofuran; hexanes T=0 - 20°C; 2.5 h;
参考文献
JANSSEN PHARMACEUTICA NV; BREITENBUCHER, Guy, J.; TICHENOR, Mark, S.; MERIT, Jeffrey, E.; HAWRYLUK, Natalie, A.; CHAMBERS, Alison, L.; KEITH, John, M.
Patent: WO2010/141809 A1, 2010 ;
Location in patent: Page/Page column 67-68 ;
WO 2010/141809 A1
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: 1-(t-butoxycarbonyl)-3-pyrrolidinecarboxaldehyde in tetrahydrofuran; hexane T=22°C; 2.5 h;
参考文献
Aventis Pharma S.A.; Targacept, Inc.
Patent: US2004/176348 A1, 2004 ;
Location in patent: Page/Page column 10 ;
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran T=0°C;
参考文献
MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;
Location in patent: Page/Page column 239-241 ;
