2-甲基-3-硝基苯甲酸甲酯合成路线 （共 49 条）
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 20, p. 169
反应条件
1: 98 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CH2Cl2 / 16 h / Heating 2: 81 percent / ammonia / methanol / 2 h / 20 °C View Scheme
参考文献
Fu, Liqiang; Liu, Xin; Ling, Chenyu; Cheng, Jianjun; Guo, Xingsheng; He, Huili; Ding, Shi; Yang, Yushe
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 814 - 819
反应条件
in N,N-dimethyl-formamide
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US6495541 B1, 2002 ;
反应条件
1: 92 percent / CuI; DMF / 0.67 h / 180 °C / 6000.6 - 7500.75 Torr / microwave irradiation 2: 65 percent / H2 / Pd/C / methanol; CH2Cl2 / 20 °C View Scheme
参考文献
Soederberg, Bjoern C.; Shriver, James A.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5838 - 5845
反应条件
1: 98 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CH2Cl2 / 16 h / Heating 2: 81 percent / ammonia / methanol / 2 h / 20 °C 3: 83 percent / ammonium formate / Pd/C / dimethylformamide / 0.5 h / 100 °C View Scheme
参考文献
Jagtap, Prakash G.; Southan, Garry J.; Baloglu, Erkan; Ram, Siya; Mabley, Jon G.; Marton, Anita; Salzman, Andrew; Szabo, Csaba
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 81 - 85
反应条件
1: dimethylformamide / 12 h / 120 °C 2: H2 / 10 percent Pd/C / benzene / 12 h / 2844.31 Torr / Ambient temperature 3: 100 percent / DMAP / acetonitrile / 12 h / Ambient temperature 4: 88 percent / DIBAL / diethyl ether; CH2Cl2 / 0.5 h / -78 °C View Scheme
参考文献
Fauq, Abdul H.; Hong, Feng; Cusack, Bernadette; Tyler, Beth M.; Ping-Pang, Yuan; Richelson, Elliott
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4127 - 4134
反应条件
1: dimethylformamide / 12 h / 120 °C 2: H2 / 10 percent Pd/C / benzene / 12 h / 2844.31 Torr / Ambient temperature 3: 100 percent / DMAP / acetonitrile / 12 h / Ambient temperature View Scheme
参考文献
Fauq, Abdul H.; Hong, Feng; Cusack, Bernadette; Tyler, Beth M.; Ping-Pang, Yuan; Richelson, Elliott
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4127 - 4134
反应条件
1: dimethylformamide / 12 h / 120 °C 2: H2 / 10 percent Pd/C / benzene / 12 h / 2844.31 Torr / Ambient temperature 3: 100 percent / DMAP / acetonitrile / 12 h / Ambient temperature 4: 88 percent / DIBAL / diethyl ether; CH2Cl2 / 0.5 h / -78 °C 5: 84 percent / PBr3 / diethyl ether; CH2Cl2 / 0.5 h / 0 °C View Scheme
参考文献
Fauq, Abdul H.; Hong, Feng; Cusack, Bernadette; Tyler, Beth M.; Ping-Pang, Yuan; Richelson, Elliott
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4127 - 4134
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 72 h; Heating / reflux;
参考文献
Huang, Qi; Kaller, Matthew; Nguyen, Thomas; Norman, Mark H.; Rzasa, Robert; Wang, Hui-Ling; Zhong, Wenge
Patent: US2003/229068 A1, 2003 ;
Location in patent: Page 39 ;
US 20030229068 A1
反应条件
1: Fe; HOAc 2: Red-Al(R) View Scheme
参考文献
Haskins, Charlotte M.; Knight, David W.
Chemical Communications, 2005 , # 25 p. 3162 - 3164
