2-甲基-3-硝基苯甲酸甲酯合成路线 （共 49 条）
反应条件
hydrogen; palladium in methanol P=2585.81 Torr;
参考文献
WO2005/28445 A2, ;
Page/Page column 28 ;
WO 2005/028445 A2
反应条件
hydrogenchloride in methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=20 - 50°C; 12.5 h;
参考文献
Kuethe, Jeffrey T.; Davies, Ian W.
Tetrahedron, 2006 , vol. 62, # 49 p. 11381 - 11390
反应条件
1: NBS / CCl4 / Heating; Irradiation 2: Et3N / dimethylformamide / 80 °C 3: H2 / 10 percent Pd/C / methanol View Scheme
参考文献
RATIOPHARM GMBH; STIEGEL, Hans-Huenter^, Dr.; ALBRECHT, Wolfgang, Dr.; BRUECK, Sandra; PAETZ, Jana; MEERGANS, Dominique
Patent: WO2011/50962 A1, 2011 ;
反应条件
sodium borohydride in methanol; chloroform; water; tert-butyl alcohol
参考文献
Nissan Chemical Industries Ltd.
Patent: US4942246 A1, 1990 ;
反应条件
1: 98 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CH2Cl2 / 16 h / Heating
2: 81 percent / ammonia / methanol / 2 h / 20 °C
3: 83 percent / ammonium formate / Pd/C / dimethylformamide / 0.5 h / 100 °C
4: aq. NaHCO3 / ethyl acetate / 0.5 h / 20 °C
5: NaOH / methanol / 20 °C
View Scheme
参考文献
Jagtap, Prakash G.; Southan, Garry J.; Baloglu, Erkan; Ram, Siya; Mabley, Jon G.; Marton, Anita; Salzman, Andrew; Szabo, Csaba
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 81 - 85
反应条件
1: 1.) DMF, reflux, 10 h; 2.) water
2: 18.1 percent / dimethylformamide / 12 h / Heating
3: 86.6 percent / TiCl3 / acetic acid; H2O / 0.12 h
View Scheme
参考文献
Somei; Karasawa; Shoda; Kaneko
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 249 - 253
反应条件
in N,N-dimethyl-formamide
T=130°C; 8 h;
参考文献
Collins, Michael P.; Drew, Michael G. B.; Mann, John; Finch, Harry
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 23 p. 3211 - 3218
反应条件
1: 93 percent / dimethylformamide / 8 h / 130 °C
2: 68 percent / H2 / 10percent Pd-C / benzene / 6.5 h / 2585.7 Torr
3: 87 percent / DIBAL / CH2Cl2; diethyl ether / 4 h / -78 °C
4: 68 percent / MnO2 / CH2Cl2 / Ambient temperature
5: 90 percent / glacial HOAc / 3.5 h / 0 °C
View Scheme
参考文献
Collins, Michael P.; Drew, Michael G. B.; Mann, John; Finch, Harry
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 23 p. 3211 - 3218
反应条件
in DMF (N,N-dimethyl-formamide)
T=130°C; 12 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2005/34939 A1, 2005 ;
Location in patent: Page/Page column 56 ;
