2-氯-5-(2-氧代丙基)苯磺酰氯合成路线 （共 3 条）
反应条件
chlorosulfonic acid
T=-10 - 20°C; 36 h;
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2007/129048 A1, 2007 ;
Location in patent: Page/Page column 34 ;
WO 2007/129048 A1
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2007/129005 A1, 2007 ;
Location in patent: Page/Page column 27-28 ;
WO 2007/129005 A1
反应条件
1: 2-chloro-5-(2-oxopropyl)-benzenesulphonyl-chloride With hydrogenchloride; sodium hydrogencarbonate; sodium sulfite in 1,4-dioxane; water
T=70°C; 1 h;
2: methyl iodide in DMF (N,N-dimethyl-formamide)
T=40°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/78754 A1, 2004 ;
Location in patent: Page 37-38 ;
WO 2004/078754 A1
