2-甲基-2-羟基丙酸合成路线 （共 177 条）
参考文献
Crombie,L. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 2976 - 2981
反应条件
boric acid in toluene 16 h; Heating;
参考文献
Maki, Toshikatsu; Ishihara, Kazuaki; Yamamoto, Hisashi
Organic Letters, 2005 , vol. 7, # 22 p. 5047 - 5050
反应条件
toluene-4-sulfonic acid T=190 - 210°C;
参考文献
Am. Cyanamid Co.
Patent: US2336317 , 1940 ;
反应条件
in water T=200°C; P=37503.8 Torr; 0.00275 h;
参考文献
Sato, Masahiro; Matsushima, Keiichiro; Kawanami, Hajime; Ikuhsima, Yutaka
Angewandte Chemie - International Edition, 2007 , vol. 46, # 33 p. 6284 - 6288
反应条件
1.) 0 deg C, 50 min; 2.) RT, 20 min; 3.) reflux, 2 h;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1443041 A1, 2004 ;
Location in patent: Page 31 ;
参考文献
Crombie,L. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 2976 - 2981
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Anschuetz; Motschmann
Justus Liebigs Annalen der Chemie, 1912 , vol. 392, p. 124
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Filachione; Lengel; Fisher
Journal of the American Chemical Society, 1946 , vol. 68, p. 332
反应条件
calcinated cesium nitrate on silica T=350°C; Gas phase;
参考文献
MITSUBISHI GAS CHEMICAL COMPANY, LTD.
Patent: EP1186592 A1, 2002 ;
Location in patent: Example 4 ;
参考文献
Kahovec; Kohlrausch
Monatshefte fuer Chemie, 1943 , vol. 74, p. 115
反应条件
sulfuric acid; benzene unter azeotropem Abdestillieren des entstehenden Wassers;
参考文献
Comm.Solv.Corp.
Patent: US2029694 , 1934 ;
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Comm.Solv.Corp.
Patent: US1775636 , 1928 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide T=0 - 60°C; 2 h; Inert atmosphereSchlenk technique;
参考文献
Kanbayashi, Naoya; Takenaka, Kazuhiro; Okamura, Taka-Aki; Onitsuka, Kiyotaka
Angewandte Chemie - International Edition, 2013 , vol. 52, # 18 p. 4897 - 4901
Angew. Chem., 2013 , vol. 125, # 18 p. 4997 - 5001,5
