2-甲基-2-羟基丙酸合成路线 （共 177 条）
反应条件
potassium hydroxide; water; sodium hydride
1.) mineral oil, 120 - 130 deg C, 6 days, 2.) THF, reflux, 42 h; Yield given. Multistep reaction;
参考文献
Crout, David H. G.; McIntyre, C. Rupert; Alcock, Nathaniel W.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 1 p. 53 - 62
反应条件
pyridine in acetonitrile
T=20°C; 0.666667 h;
参考文献
ONO PHARMACEUTICALS CO., LTD.; Kokubo, Masaya; Yano, Koji
Patent: US2013/245074 A1, 2013 ;
Location in patent: Paragraph 0349-0352 ;
参考文献
Skolnik et al.
Journal of the American Chemical Society, 1943 , vol. 65, p. 1854,1856
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Siegart; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 4391,4393
反应条件
und Erhitzen des Reaktionsprodukts auf 100-150grad;
参考文献
Newman; Fones
Journal of the American Chemical Society, 1947 , vol. 69, p. 1046
反应条件
und Erhitzen des Reaktionsprodukts auf 100-150grad;
参考文献
Newman; Fones
Journal of the American Chemical Society, 1947 , vol. 69, p. 1046
反应条件
phosphorus pentachloride in benzene
参考文献
Gurarii,L.I. et al.
Doklady Chemistry, 1977 , vol. 232, p. 64 - 66
Dokl. Akad. Nauk SSSR Ser. Khim., 1977 , vol. 232, p. 1072 - 1074
反应条件
perchloric acid in acetic acid
T=24.9 - 39.9°C; 10 h; other solvent; solventisotope effect; ΔH(excit), ΔS(excit), ΔG(excit); Thermodynamic dataMechanismKinetics;
参考文献
Mathur, Abha; Sharma, Vinita; Banerji, Kalyan K.
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1988 , vol. 27, # 2 p. 123 - 125
