2-(4-氨基苯基)丙酸合成路线 （共 21 条）
反应条件
1: HgCl2 / methanol; H2O / 4 h / Heating 2: KOH / methanol / 2 h / Heating 3: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 4: H2NOH*HCl / ethanol; H2O / 24 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2801 - 2807
反应条件
1: 96 percent / AcOH / benzene / 4 h / Heating 2: 93 percent / n-BuLi / hexane; diethyl ether / 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h 3: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 4: HgCl2 / methanol; H2O / 4 h / Heating 5: KOH / methanol / 2 h / Heating 6: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 7: H2NOH*HCl / ethanol; H2O / 24 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2801 - 2807
反应条件
1: fuming nitric acid / Reaktion ueber mehrere Stufen 2: tin; hydrochloric acid View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 227, p. 274
参考文献
Hisamitsu Pharmaceutical Co., Inc.
Patent: US4400520 A1, 1983 ;
参考文献
Hisamitsu Pharmaceutical Co., Inc.
Patent: US4400520 A1, 1983 ;
反应条件
1: 96 percent / p-TsOH / toluene / 18 h / Heating 2: 69 percent / 1,2,3-1H-benzotriazole, 2-mercaptoethanol / acetonitrile; various solvent(s) / 13 h / Ambient temperature; pH 9.6 3: 83 percent / KOH / aq. ethanol / 3 h / 70 °C View Scheme
参考文献
Takahashi, Ichiro; Hirano, Etsushi; Kawakami, Teruki; Kitajima, Hidehiko
Heterocycles, 1996 , vol. 43, # 11 p. 2343 - 2346
反应条件
1: With sulfuric acid 5 h; Heating / reflux; 2: With sodium hydroxide in water T=20°C; 3: With acetic acid in water
参考文献
Gruenenthal GmbH
Patent: US2009/156590 A1, 2009 ;
Location in patent: Page/Page column 56 ;
US 20090156590 A1
反应条件
1: 1.) aq. HCl, NaNO2 / 1.) water, 0 deg C, 45 min, 2.) ethyl acetate, 55 deg C, 30 min 2: KOH / ethanol; H2O / 12 h / Heating 3: 1.) K2CO3, 2.) NaOH / 1.) DMF, 60 deg C, 5 h, 2.) ethanol/water, reflux, 5.5 h View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 55, # 5 p. 1266 - 1277
反应条件
1: 1.) aq. HCl, NaNO2 / 1.) water, 0 deg C, 45 min, 2.) ethyl acetate, 55 deg C, 30 min 2: KOH / ethanol; H2O / 12 h / Heating 3: 1.) K2CO3, 2.) NaOH / 1.) DMF, 60 deg C, 5 h, 2.) ethanol/water, reflux, 5.5 h 4: SOCl2 / hexane / 4 h / Heating 5: NH3 / diethyl ether / Ambient temperature View Scheme
参考文献
Jilek, Jiri; Sindelar, Karel; Grimova, Jaroslava; Maturova, Eva; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 5 p. 1266 - 1277
反应条件
toluene-4-sulfonic acid in toluene 18 h; Heating;
参考文献
Takahashi, Ichiro; Hirano, Etsushi; Kawakami, Teruki; Kitajima, Hidehiko
Heterocycles, 1996 , vol. 43, # 11 p. 2343 - 2346
