3-氧代-3-(4-苯氧基苯基)丙酸乙酯合成路线 （共 4 条）
反应条件
sodium hydride in tetrahydrofuran; mineral oil T=20°C; 2.5 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BENTZIEN, Joerg Martin; BERRY, Angela Kay; BOSANAC, Todd; BURKE, Michael Jason; DISALVO, Darren Todd; HORAN, Joshua Courtney; LIANG, Shuang; MAO, Can; MAO, Wang; SHEN, Yue; SOLEYMANZADEH, Fariba; ZINDELL, Renee M.
Patent: US2014/45813 A1, 2014 ;
Location in patent: Paragraph 0141 ;
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile T=20°C; 2.5 h; 2: 2-Phenoxybenzoic acid chloride in acetonitrile T=0 - 20°C; 5.41667 h;
参考文献
EP1140895 B1, ;
Page 47 ;
反应条件
1: (4'-phenoxyphenyl)methylketone With sodium hydride in tetrahydrofuran Heating / reflux; 2: carbonic acid diethyl ester in tetrahydrofuran
参考文献
WO2007/117692 A2, ;
Page/Page column 20 ;
WO 2007/117692 A2
反应条件
sulfuric acid 3 h; Heating;
参考文献
Tomisawa; Kameo; Matsunaga; Saito; Hosoda; Asami; Sota
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 701 - 712
