4-氯-2-(2-噻吩)喹唑啉合成路线 （共 8 条）
参考文献
Signal Pharmaceuticals, Inc.
Patent: US5939421 A1, 1999 ;
反应条件
1: tetrahydrofuran / 2 h / 20 °C
2: Ac2O / 1 h / Heating
3: AcONH4 / 7 h / 220 °C
4: POCl3 / 3 h / Heating
View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: NaOMe / toluene / 18 h / Heating
2: 1.) N,N-dimethylaniline, 2.) POCl3 / 1.) C6H6, reflux, 30 min, 2.) C6H6, reflux, 6 h
View Scheme
参考文献
Lee; Konishi; Yu; Miskowski; Riviello; Macina; Frierson; Kondo; Sugitani; Sircar; Blazejewski
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3547 - 3557
反应条件
1: Et3N / tetrahydrofuran; CH2Cl2 / 6 h / 23 °C
2: NaOMe / toluene / 18 h / Heating
3: 1.) N,N-dimethylaniline, 2.) POCl3 / 1.) C6H6, reflux, 30 min, 2.) C6H6, reflux, 6 h
View Scheme
参考文献
Lee; Konishi; Yu; Miskowski; Riviello; Macina; Frierson; Kondo; Sugitani; Sircar; Blazejewski
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3547 - 3557
反应条件
1: tetrahydrofuran / 2 h / 20 °C
2: Ac2O / 1 h / Heating
3: AcONH4 / 7 h / 220 °C
4: POCl3 / 3 h / Heating
View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: oxalyl dichloride / dichloromethane / 3 h / 20 °C
2: dichloromethane / 4 h
3: sodium hydroxide / ethanol / 2 h / Reflux
4: N,N-dimethyl-aniline; trichlorophosphate / 4 h / Reflux
View Scheme
参考文献
Marugan, Juan J.; Zheng, Wei; Motabar, Omid; Southall, Noel; Goldin, Ehud; Westbroek, Wendy; Stubblefield, Barbara K.; Sidransky, Ellen; Aungst, Ronald A.; Lea, Wendy A.; Simeonov, Anton; Leister, William; Austin, Christopher P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 1033 - 1058
反应条件
1: AcONH4 / 7 h / 220 °C
2: POCl3 / 3 h / Heating
View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: Ac2O / 1 h / Heating
2: AcONH4 / 7 h / 220 °C
3: POCl3 / 3 h / Heating
View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
