2,4-二氨基-5-(3-甲氧基苄基)嘧啶合成路线 （共 2 条）
反应条件
1: 1-methylguanidine hydrochloride With sodium ethanolate in ethanol
T=20°C; Metallation; 0.0833333 h;
2: 2-(ethoxymethyl)-3-(3-methoxyphenyl)-2-propenenitrile cyclocondensation; 40 h; Heating;
参考文献
Chowdhury, Shafinaz F.; Villamor, Victor Bernier; Guerrero, Ramon Hurtado; Leal, Isabel; Brun, Reto; Croft, Simon L.; Goodman, Jonathan M.; Maes, Louis; Ruiz-Perez, Luis M.; Pacanowska, Dolores Gonzalez; Gilbert, Ian H.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4300 - 4312
反应条件
1.1: 55 percent / NaOEt / ethanol / Heating
2.1: NaOEt / ethanol / 0.08 h / 20 °C
2.2: 60 percent / 40 h / Heating
View Scheme
参考文献
Chowdhury, Shafinaz F.; Villamor, Victor Bernier; Guerrero, Ramon Hurtado; Leal, Isabel; Brun, Reto; Croft, Simon L.; Goodman, Jonathan M.; Maes, Louis; Ruiz-Perez, Luis M.; Pacanowska, Dolores Gonzalez; Gilbert, Ian H.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4300 - 4312
