2-(3,5-二氯苯基)-6-苯并恶唑甲酸合成路线 (共 4 条)
反应条件
1.1: 5 h / 100 °C / Inert atmosphere 2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere 3.1: 3 h / 20 °C / Inert atmosphere 4.1: [2,2']bipyridinyl; [Ni0(1,5-cyclooctadiene)2]; lithium tert-butylate / ethylene glycol dimethyl ether / 24 h / 100 °C / Inert atmosphere 5.1: pyridine hydrogenfluoride / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere 5.2: Inert atmosphere 5.3: Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 36 p. 10113 - 10122
反应条件
1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere 2.1: 3 h / 20 °C / Inert atmosphere 3.1: [2,2']bipyridinyl; [Ni0(1,5-cyclooctadiene)2]; lithium tert-butylate / ethylene glycol dimethyl ether / 24 h / 100 °C / Inert atmosphere 4.1: pyridine hydrogenfluoride / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere 4.2: Inert atmosphere 4.3: Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 36 p. 10113 - 10122
反应条件
1.1: [2,2']bipyridinyl; [Ni0(1,5-cyclooctadiene)2]; lithium tert-butylate / ethylene glycol dimethyl ether / 24 h / 100 °C / Inert atmosphere 2.1: pyridine hydrogenfluoride / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere 2.2: Inert atmosphere 2.3: Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 36 p. 10113 - 10122
反应条件
1.1: pyridine / tetrahydrofuran / 11 h / 20 °C / |Reflux 2.1: toluene-4-sulfonic acid / anhydrous xylene / 12 h / |Reflux 2.2: 25 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 20 °C View Scheme