5-氯-2,3-二甲基吡嗪合成路线 （共 6 条）
反应条件
1: 46 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) room temp. 12 h 2) reflux, 5 h 2: 38 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Watahiki, Hiroko; Tsutsui, Mayumi; Akita, Yasuo; Watanabe, Tokuhiro; Kurihara, Teruo
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 465 - 473
反应条件
trichlorophosphate
2 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/100670 A1, 2007 ;
Location in patent: Page/Page column 49-50 ;
WO 2007/100670 A1
反应条件
phosphorus pentachloride; trichlorophosphate
参考文献
Karmas; Spoerri
Journal of the American Chemical Society, 1952 , vol. 74, p. 1580,1582
反应条件
1: 46 percent / 30percent H2O2, acetic acid / 16 h / 50 - 60 °C
2: 17 percent / POCl3 / 0.5 h / Heating
View Scheme
参考文献
Watahiki, Hiroko; Tsutsui, Mayumi; Akita, Yasuo; Watanabe, Tokuhiro; Kurihara, Teruo
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 465 - 473
反应条件
trichlorophosphate
0.5 h; Heating;
参考文献
Watahiki, Hiroko; Tsutsui, Mayumi; Akita, Yasuo; Watanabe, Tokuhiro; Kurihara, Teruo
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 465 - 473
反应条件
T=550°C; Yield given. Yields of byproduct given;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430
