5-苯并[1,3]二氧杂环戊烯-5-基-N-(2-甲基丙基)戊-2,4-二烯酰胺合成路线 （共 19 条）
反应条件
1: piperic acid With thionyl chloride in dichloromethane
1 h; Reflux;
2: isobutylamine in dichloromethane
1 h;
参考文献
Sangwan, Payare L.; Koul, Jawahir L.; Koul, Surrinder; Reddy, Mallepally V.; Thota, Niranjan; Khan, Inshad A.; Kumar, Ashwani; Kalia, Nitin P.; Qazi, Ghulam N.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9847 - 9857
反应条件
triethylamine in tetrahydrofuran
T=60°C; Acylation;
参考文献
De Paula, Vanderlucia F.; De A Barbosa, Luiz C.; Demuner, Antonio J.; Pilo-Veloso, Dorila; Picanco, Marcelo C.
Pest Management Science, 2000 , vol. 56, # 2 p. 168 - 174
反应条件
aluminum oxide; potassium hydroxide; dibromo-difluoro-methane in dichloromethane
T=20°C; 1 h;
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1: (E)-3-(benzo[1,3]dioxol-5-yl)acrylic acid With N-bromosuccinmide; tetrabutyl-ammonium trifluoroacetate in 1,2-dichloro-ethane
T=20°C; Decarboxylation; bromination; Hunsdiecker reaction; 4 h;
2: N-(2-methylpropyl)prop-2-enamide With palladium diacetate; tri-phenyl-antimony; triethylamine in 1,2-dichloro-ethane
Heck reaction; 20 h;
参考文献
Naskar, Dinabandhu; Roy, Sujit
Tetrahedron, 2000 , vol. 56, # 10 p. 1369 - 1377
反应条件
pyridine; methanesulfonyl chloride
Ambient temperature;
参考文献
Majewski, M.; Mpango, G. B.; Thomas, M. T.; Wu, A.; Snieckus, V.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2029 - 2045
反应条件
1: 60 percent / KOH / methanol / 2 h / Heating
2: Et3N / CH2Cl2 / 0.5 h / 0 °C
3: 120 mg / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Venkatasamy, Radhakrishnan; Faas, Laura; Young, Antony R.; Raman, Amala; Hider, Robert C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1905 - 1920
反应条件
1: Et3N / CH2Cl2 / 0.5 h / 0 °C
2: 120 mg / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Venkatasamy, Radhakrishnan; Faas, Laura; Young, Antony R.; Raman, Amala; Hider, Robert C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1905 - 1920
反应条件
1.1: benzene / 4 h / Heating
2.1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C
3.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
4.1: KOH / methanol / 0.17 h / 0 °C
4.2: 68 percent / methanol / 1 h / 0 °C
5.1: 94 percent / oxone / methanol; H2O / 0 °C
6.1: 84 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1: methanol / 15 h / 20 °C
2: 80 percent / tetrahydrofuran / 2 h / 20 °C
3: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
4: 76 percent / DCC; DMAP
View Scheme
参考文献
Chandrasekhar; Venkat Reddy; Srinivasa Reddy; Ramarao
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2667 - 2670
反应条件
1: 80 percent / tetrahydrofuran / 2 h / 20 °C
2: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
3: 76 percent / DCC; DMAP
View Scheme
参考文献
Chandrasekhar; Venkat Reddy; Srinivasa Reddy; Ramarao
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2667 - 2670
