5-苯并[1,3]二氧杂环戊烯-5-基-N-(2-甲基丙基)戊-2,4-二烯酰胺合成路线 （共 19 条）
反应条件
1: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
2: 76 percent / DCC; DMAP
View Scheme
参考文献
Chandrasekhar; Venkat Reddy; Srinivasa Reddy; Ramarao
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2667 - 2670
反应条件
in dichloromethane
T=0 - 20°C; 3 h;
参考文献
Venkatasamy, Radhakrishnan; Faas, Laura; Young, Antony R.; Raman, Amala; Hider, Robert C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1905 - 1920
反应条件
1.1: KOH / methanol / 0.17 h / 0 °C
1.2: 68 percent / methanol / 1 h / 0 °C
2.1: 94 percent / oxone / methanol; H2O / 0 °C
3.1: 84 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1: 94 percent / oxone / methanol; H2O / 0 °C
2: 84 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
2.1: KOH / methanol / 0.17 h / 0 °C
2.2: 68 percent / methanol / 1 h / 0 °C
3.1: 94 percent / oxone / methanol; H2O / 0 °C
4.1: 84 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1.1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C
2.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
3.1: KOH / methanol / 0.17 h / 0 °C
3.2: 68 percent / methanol / 1 h / 0 °C
4.1: 94 percent / oxone / methanol; H2O / 0 °C
5.1: 84 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1: 100 percent / KOH / methanol / 6 h / Heating
2: 91 percent / B(OH)3 / toluene / 16 h / Heating
View Scheme
参考文献
Seung, Ho Lee; Dong, Hyun Kim; Jeong, Ah Kim; Jahng, Yurngdong
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 407 - 410
反应条件
1: 100 percent / KOH / methanol / 6 h / Heating
2: 91 percent / B(OH)3 / toluene / 16 h / Heating
View Scheme
参考文献
Seung, Ho Lee; Dong, Hyun Kim; Jeong, Ah Kim; Jahng, Yurngdong
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 407 - 410
反应条件
1: 1.) LDA / 1.) THF, RT, 0.5 h, 2.) -78 deg C to -5 deg C, 1 h
2: 84 percent / methanesulfonyl chloride, pyridine / Ambient temperature
View Scheme
参考文献
Majewski, M.; Mpango, G. B.; Thomas, M. T.; Wu, A.; Snieckus, V.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2029 - 2045
