1-甲基-1H -吡唑- 4 -羧酸甲酯合成路线 （共 10 条）
反应条件
N-chloro-succinimide T=120°C; Yield given. Yields of byproduct given;
参考文献
Morimoto, Katsushi; Sato, Toshiaki; Yamamoto, Susumu; Takeuchi, Hiroshi
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 537 - 540
反应条件
1: N-chlorosuccinimide / 120 °C 2: 73 percent / N-chlorosuccinimide / 160 °C View Scheme
参考文献
Morimoto, Katsushi; Sato, Toshiaki; Yamamoto, Susumu; Takeuchi, Hiroshi
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 537 - 540
反应条件
1: N-chlorosuccinimide / 120 °C 2: 73 percent / N-chlorosuccinimide / 160 °C 3: 96 percent / 70percent sodium hydrosulfide / dimethylformamide / 0.5 h / 60 °C View Scheme
参考文献
Morimoto, Katsushi; Sato, Toshiaki; Yamamoto, Susumu; Takeuchi, Hiroshi
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 537 - 540
反应条件
sulfuric acid; iodine; iodic acid in tetrachloromethane; acetic acid T=80°C; 30 h; Further byproducts given;
参考文献
Vasilevskii, S. F.; Shvartsberg, M. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 5 p. 778 - 784
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 5 p. 1071 - 1077
反应条件
1: N-chlorosuccinimide / 120 °C 2: 73 percent / N-chlorosuccinimide / 160 °C 3: 96 percent / 70percent sodium hydrosulfide / dimethylformamide / 0.5 h / 60 °C 4: 1.) chlorine, aq. AcOH, 2.) 28percent aq. NH3 / 1.) 5 deg C, 2.) 1,2-dichloroethane, RT, 0.5 h View Scheme
参考文献
Morimoto, Katsushi; Sato, Toshiaki; Yamamoto, Susumu; Takeuchi, Hiroshi
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 537 - 540
反应条件
methanol in hexanes
T=0°C; 0.333333 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRADL, Stefan; RUDOLPH, Joachim; REN, Li
Patent: WO2011/25951 A1, 2011 ;
Location in patent: Page/Page column 54 ;
WO 2011/025951 A1
反应条件
palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane
T=100°C; P=11251.1 Torr; continuous flow reactor;
参考文献
Koos, Peter; Gross, Ulrike; Polyzos, Anastasios; O'Brien, Matthew; Baxendale, Ian; Ley, Steven V.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6903 - 6908
反应条件
hydrogenchloride; sodium nitrite; sulfur dioxide
1) < 10 deg C, 10 min, 2) CCl4, room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
参考文献
Vasilevskii, S. F.; Shvartsberg, M. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 5 p. 778 - 784
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 5 p. 1071 - 1077
反应条件
in toluene
Cycloaddition; 1 h; Heating;
参考文献
Washizuka, Ken-Ichi; Nagai, Keiko; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo
Tetrahedron Letters, 1999 , vol. 40, # 50 p. 8849 - 8853
