(2-氯苯基)-(4-甲基苯基)甲酮合成路线 （共 17 条）
反应条件
1: para-bromotoluene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: 2-chloro-benzaldehyde in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
3: With iodine; potassium carbonate in tert-butyl alcohol
16 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
反应条件
antimony(V) pentachloride; N-benzyl-N,N,N-triethylammonium chloride in nitromethane
Friedel-Crafts acylation; 2.5 h; Heating;
参考文献
Huang, An-Ping; Liu, Xue-Yuan; Li, Lian-Hua; Wu, Xiao-Li; Liu, Wei-Min; Liang, Yong-Min
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 6 p. 599 - 602
反应条件
potassium fluoride; 18-crown-6 ether in tetrahydrofuran
T=0°C; 9 h;
参考文献
Yoshida, Hiroto; Mimura, Yasuhiro; Ohshita, Joji; Kunai, Atsutaka
Chemical Communications, 2007 , # 23 p. 2405 - 2407
反应条件
anhydrous iron chloride; potassium acetate; sodium hydrogencarbonate; iron(II) chloride
T=100°C; Suzuki Coupling; P=760.051 Torr; 24 h; Schlenk technique;
参考文献
Zhong, Yanzhen; Han, Wei
Chemical Communications, 2014 , vol. 50, # 29 p. 3874 - 3877
反应条件
phosphorus pentoxide adsorbed onto silica
Friedel Crafts acylation; Reflux; regioselective reaction;
参考文献
Faridoon; Hussein, Waleed M.; Vella, Peter; Islam, Nazar Ul; Ollis, David L.; Schenk, Gerhard; McGeary, Ross P.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 380 - 386
反应条件
pyridinium chlorochromate in dichloromethane
T=20°C; 15 h;
参考文献
Sui, Yao-Zong; Zhang, Xi-Chang; Wu, Jun-Wen; Li, Shijun; Zhou, Ji-Ning; Li, Min; Fang, Wenjun; Chan, Albert S. C.; Wu, Jing
Chemistry - A European Journal, 2012 , vol. 18, # 24 p. 7486 - 7492
反应条件
aluminium trichloride
参考文献
De Tar; Relyea
Journal of the American Chemical Society, 1956 , vol. 78, p. 4302,4304
反应条件
1.1: magnesium / tetrahydrofuran / 1 h / Reflux
1.2: 0 °C / Inert atmosphere
2.1: pyridinium chlorochromate / dichloromethane / 15 h / 20 °C
View Scheme
参考文献
Sui, Yao-Zong; Zhang, Xi-Chang; Wu, Jun-Wen; Li, Shijun; Zhou, Ji-Ning; Li, Min; Fang, Wenjun; Chan, Albert S. C.; Wu, Jing
Chemistry - A European Journal, 2012 , vol. 18, # 24 p. 7486 - 7492
反应条件
1.1: magnesium / tetrahydrofuran / 1 h / Reflux
1.2: 0 °C / Inert atmosphere
2.1: pyridinium chlorochromate / dichloromethane / 15 h / 20 °C
View Scheme
参考文献
Sui, Yao-Zong; Zhang, Xi-Chang; Wu, Jun-Wen; Li, Shijun; Zhou, Ji-Ning; Li, Min; Fang, Wenjun; Chan, Albert S. C.; Wu, Jing
Chemistry - A European Journal, 2012 , vol. 18, # 24 p. 7486 - 7492
反应条件
hydrogenchloride; magnesium
Multistep reaction;
参考文献
Almansa, Carmen; Gomez, Luis A.; Cavalcanti, Fernando L.; De Arriba, Alberto F.; Rodriguez, Ricardo; Carceller, Elena; Garcia-Rafanell, Julian; Forn, Javier
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2197 - 2206
