(2S,3R)-3-氨基-2-羟基-4-苯丁酸合成路线 （共 35 条）
反应条件
1: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C 2: NEt3 / CH2Cl2 / Ambient temperature 3: 70 percent / HCl 4: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 5: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 6: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 3031 - 3034
反应条件
1: 80 percent / DIBAL / diethyl ether; hexane / 0.33 h / -78 °C 2: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C 3: NEt3 / CH2Cl2 / Ambient temperature 4: 70 percent / HCl 5: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 6: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 7: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 3031 - 3034
反应条件
1: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 2: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 3: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 3031 - 3034
反应条件
1: NEt3 / CH2Cl2 / Ambient temperature 2: 70 percent / HCl 3: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 4: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 5: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 3031 - 3034
反应条件
1: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 2: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 3031 - 3034
反应条件
1: 70 percent / HCl 2: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 3: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 4: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 3031 - 3034
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 510 - 515
反应条件
1: 92 percent / sulfuryl chloride / CHCl3 / 20 °C 2: 82 percent / Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; glucose; air / KPi buffer; XAD-4 resin / 24 h / 30 °C / pH 5.6 3: 99 percent / potassium carbonate / H2O; dimethylformamide / 5 h / 20 °C 4: 78 percent / BF3*Et2O / 0 - 20 °C 5: hydrochloric acid / H2O; ethanol / 8 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 18 p. 3124 - 3127
反应条件
1: 82 percent / Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; glucose; air / KPi buffer; XAD-4 resin / 24 h / 30 °C / pH 5.6 2: 99 percent / potassium carbonate / H2O; dimethylformamide / 5 h / 20 °C 3: 78 percent / BF3*Et2O / 0 - 20 °C 4: hydrochloric acid / H2O; ethanol / 8 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 18 p. 3124 - 3127
反应条件
2: H2 / Pd View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 510 - 515
