3-硝基-4-甲氧基苯胺磺酰基乙酸合成路线 （共 4 条）
反应条件
sodium hydroxide in water
T=20°C; 3 h; Inert atmosphere;
参考文献
Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586
反应条件
1: triethylamine / dichloromethane / 3 h / 20 °C / |Inert atmosphere
2: sodium hydroxide / water / 3 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586
反应条件
1: potassium hydroxide / 0.5 h / 20 °C / |Inert atmosphere
2: triethylamine / dichloromethane / 3 h / 20 °C / |Inert atmosphere
3: sodium hydroxide / water / 3 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586
反应条件
1: acetic acid; benzylamine / 8 h / 20 °C / |Reflux; |Inert atmosphere
2: sodium dithionite / water; acetone / 0.5 h / 50 °C / |Inert atmosphere
View Scheme
参考文献
Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586
