1,8-二叠氮基-3,5-二氧杂辛烷合成路线 （共 12 条）
反应条件
1: 98 percent / silver(I) oxide; potassium iodide / CH2Cl2 / 20 °C
2: sodium azide / dimethylformamide / 80 °C
View Scheme
参考文献
Bouzide, Abderrahim; LeBerre, Nicolas; Sauve, Gilles
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8781 - 8783
反应条件
1.1: hydrogenchloride; triphenylphosphine / water; toluene / 16 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 0.83 h
3.1: triphenylphosphine / tetrahydrofuran / 5 h
3.2: 2 h
4.1: sodium hydrogencarbonate / water / 1.25 h / 0 - 20 °C / Saturated solution
5.1: dichloromethane / 0.17 h
View Scheme
参考文献
Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S.
ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781
