4-(2-吡啶基)苯甲醚合成路线 （共 81 条）
反应条件
potassium phosphate; palladium diacetate; triphenylphosphine in 1,4-dioxane
T=110°C; Suzuki-Miyaura Coupling; 7 h; Inert atmosphereSchlenk techniqueSealed tube;
参考文献
Quan, Zheng-Jun; Jing, Fu-Qiang; Zhang, Zhang; Da, Yu-Xia; Wang, Xi-Cun
European Journal of Organic Chemistry, 2013 , # 31 p. 7175 - 7183
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethanol
T=100°C; Suzuki Coupling; 18 h; Inert atmosphere;
参考文献
Goggins, Sean; Rosevere, Eleanor; Bellini, Clement; Allen, Joseph C.; Marsh, Barrie J.; Mahon, Mary F.; Frost, Christopher G.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 47 - 52
反应条件
P(NC5H10)3; nickel dichloride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=60°C; Negishi cross-coupling reaction; 1 h;
参考文献
Gerber, Roman; Frech, Christian M.
Chemistry - A European Journal, 2011 , vol. 17, # 42 p. 11893 - 11904
反应条件
morpholine; C31H45Cl2N3OPd; caesium carbonate in water
T=110°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Wang, Zhan-Yong; Ma, Qin-Na; Li, Ren-Hao; Shao, Li-Xiong
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 45 p. 7899 - 7906
反应条件
copper(l) iodide; cesium fluoride in N,N-dimethyl-formamide
T=120°C; Hiyama Coupling; 12 h; Inert atmosphere;
参考文献
Gurung, Santosh K.; Thapa, Surendra; Vangala, Adarsh S.; Giri, Ramesh
Organic Letters, 2013 , vol. 15, # 20 p. 5378 - 5381
反应条件
potassium fluoride; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
T=120°C;
参考文献
Hatanaka, Yasuo; Goda, Ken-ichi; Okahara, Yoshinori; Hiyama, Tamejiro
Tetrahedron, 1994 , vol. 50, # 28 p. 8301 - 8316
反应条件
CoCl2 in tetrahydrofuran; diethyl ether
T=-40°C; 72 h;
参考文献
Korn, Tobias J.; Cahiez, Gerard; Knochel, Paul
Synlett, 2003 , # 12 p. 1892 - 1894
反应条件
caesium carbonate; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride; palladium diacetate in 1,4-dioxane
T=120°C; P=37503 Torr; 45 h;
参考文献
Maerten, Eddy; Sauthier, Mathieu; Mortreux, Andre; Castanet, Yves
Tetrahedron, 2007 , vol. 63, # 3 p. 682 - 689
反应条件
1: 4-methoxyphenyl magnesium bromide With PPh3 gold(I) chloro complex in tetrahydrofuran
T=-20 - 20°C; Inert atmosphere;
2: 2-iodo-pyridine With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in acetonitrile
Inert atmosphere;
参考文献
Hashmi, A. Stephen K.; Lothschuetz, Christian; Doepp, Rene; Rudolph, Matthias; Ramamurthi, Tanuja D.; Rominger, Frank
Angewandte Chemie - International Edition, 2009 , vol. 48, # 44 p. 8243 - 8246
反应条件
C42H64O4P2Pd in tetrahydrofuran
T=60°C; Kumada-Corriu coupling reaction; 20 h; Inert atmosphere; chemoselective reaction;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.; Kapdi, Anant R.; Schulzke, Carola
Chemistry - A European Journal, 2010 , vol. 16, # 11 p. 3300 - 3303
