4-(2-吡啶基)苯甲醚合成路线 （共 81 条）
反应条件
NiCl2(PCy3)2 in benzene
T=45°C; 22 h;
参考文献
Hirner, Joshua J.; Blum, Suzanne A.
Organometallics, 2011 , vol. 30, # 6 p. 1299 - 1302
反应条件
1: 2-hydroxy-pyridine With potassium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane
T=100°C; 3 h; Inert atmosphere;
2: (4-methoxyphenyl)-boronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water
T=100°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Li, Shui-Ming; Huang, Jie; Chen, Guo-Jun; Han, Fu-She
Chemical Communications, 2011 , vol. 47, # 48 p. 12840 - 12842
反应条件
C32H26ClN2NiP in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=85°C; 12 h; Inert atmosphere;
参考文献
Zhang, Xue-Qi; Wang, Zhong-Xia
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3658 - 3663
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate in 1,4-dioxane
T=110°C; 12 h; Inert atmosphereSealed tubeSchlenk technique; chemoselective reaction;
参考文献
Quan, Zheng-Jun; Lv, Ying; Jing, Fu-Qiang; Jia, Xiao-Dong; Huo, Cong-De; Wang, Xi-Cun
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 2-3 p. 325 - 332
反应条件
C27H22Cl2N3NiP in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
0.5 h; Inert atmosphereSchlenk techniqueHeating;
参考文献
Zhang, Qiang; Zhang, Xue-Qi; Wang, Zhong-Xia
Dalton Transactions, 2012 , vol. 41, # 34 p. 10453 - 10464,12
反应条件
copper acetylacetonate; potassium tert-butylate; oxygen in toluene
T=110°C; 2 h;
参考文献
Shen, Yan; Chen, Jiuxi; Liu, Miaochang; Ding, Jinchang; Gao, Wenxia; Huang, Xiaobo; Wu, Huayue
Chemical Communications, 2014 , vol. 50, # 33 p. 4292 - 4295
反应条件
potassium carbonate in ethanol; water
T=90°C; Suzuki Coupling; 0.5 h; Microwave irradiation;
参考文献
Bratt, Emma; Verho, Oscar; Johansson, Magnus J; Baeckvall, Jan-Erling
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3946 - 3954
反应条件
methylamine in ethanol
T=140°C; 40 h;
参考文献
Blokhin, A. V.; Tyurekhodzhaeva, M. A.; Bazhenov, D. V.; Bobrovskii, S. I.; Bundel', Yu. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 9 p. 1022 - 1025
Khimiya Geterotsiklicheskikh Soedinenii, 1990 , vol. 26, # 9 p. 1226 - 1229
反应条件
1: 4-methoxyphenyl triflate With tris-(dibenzylideneacetone)dipalladium(0); (1-Ad)2P(O)H in tetrahydrofuran
Kumada-Corriu coupling reaction; 0.0833333 h; Inert atmosphere;
2: (pyridin-2-yl)magnesium bromide in tetrahydrofuran
T=60°C; Kumada-Corriu coupling reaction; 20 h; Inert atmosphere; chemoselective reaction;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.; Kapdi, Anant R.; Schulzke, Carola
Chemistry - A European Journal, 2010 , vol. 16, # 11 p. 3300 - 3303
反应条件
copper(I) oxide; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; palladium dichloride in N,N-dimethyl acetamide
T=150°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Li, Xinjian; Zou, Dapeng; Leng, Faqiang; Sun, Chunxia; Li, Jingya; Wu, Yangjie; Wu, Yusheng
Chemical Communications, 2013 , vol. 49, # 3 p. 312 - 314
