4-(2-吡啶基)苯甲醚合成路线 （共 81 条）
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h; Inert atmosphere;
2: With zinc trimethylacetate in tetrahydrofuran; hexane
T=-78 - 25°C; Inert atmosphere;
3: 1-methoxy-4-chlorobenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran
T=50°C; Negishi Coupling; 12 h; Inert atmosphereSchlenk technique; SolventReagent/catalyst;
参考文献
Colombe, James R.; Bernhardt, Sebastian; Stathakis, Christos; Buchwald, Stephen L.; Knochel, Paul
Organic Letters, 2013 , vol. 15, # 22 p. 5754 - 5757
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate; acetic acid in water
T=50°C; 24 h;
参考文献
Koley, Moumita; Wimmer, Laurin; Schnuerch, Michael; Mihovilovic, Marko D.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1368 - 1373
反应条件
[Co(η5-C5H5)2] in tetrahydrofuran
T=150 - 160°C; P=9120 - 12160 Torr; 2.5 h; Yield given;
参考文献
Kayushina, E. N.; Levin, D. Z.; Mortikov, E. S.; Promonenkov, V. K.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, p. 1474 - 1477
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 7 p. 1625 - 1628
反应条件
Cp2Ni; potassium tert-butylate; triphenylphosphine
T=100°C; 12 h; Inert atmosphere;
参考文献
Kobayashi, Osamu; Uraguchi, Daisuke; Yamakawa, Tetsu
Organic Letters, 2009 , vol. 11, # 12 p. 2679 - 2682
反应条件
tBu2P-N=P(iBuPCH2CH2)3N; tetrabutyl ammonium fluoride; palladium diacetate
T=80°C; Hiyama coupling; 2 h; Inert atmosphereNeat (no solvent);
参考文献
Raders, Steven M.; Kingston, Jesudoss V.; Verkade, John G.
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1744 - 1747
反应条件
potassium tert-butylate
T=110°C; 8 h;
参考文献
Bhakuni, Bhagat Singh; Yadav, Abhimanyu; Kumar, Shailesh; Kumar, Sangit
New Journal of Chemistry, 2014 , vol. 38, # 2 p. 827 - 836
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 16 h / 20 °C
1.2: 75 percent / isopropanol / tetrahydrofuran; hexane / 4 h / Heating
2.1: 85 percent / Pd(OAc)2; K2CO3; tris(o-tolyl)phosphine / CuI / tetrahydrofuran / Heating
View Scheme
参考文献
Hodgson, Paul B.; Salingue, Fabrice H.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 685 - 687
反应条件
1: methoxybenzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl2*TMEDA in tetrahydrofuran; hexane
T=0 - 20°C; Inert atmosphere;
2: 2-bromo-pyridine With 1,1'-bis-(diphenylphosphino)ferrocene; palladium dichloride in tetrahydrofuran; hexane
24 h; RefluxInert atmosphere;
参考文献
Snegaroff, Katia; Komagawa, Shinsuke; Chevallier, Floris; Gros, Philippe C.; Golhen, Stephane; Roisnel, Thierry; Uchiyama, Masanobu; Mongin, Florence
Chemistry - A European Journal, 2010 , vol. 16, # 27 p. 8191 - 8201
反应条件
hydrogenchloride; sodium nitrite
参考文献
Leclerc, Gerard; Marciniak, Gilbert; Decker, Nicole; Schwartz, Jean
Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2427 - 2432
反应条件
tetrakis(triphenylphosphine) palladium(0); hexamethyl-distannane; lithium chloride in 1,4-dioxane
Heating;
参考文献
Hitchcock; Mayhugh; Gregory
Tetrahedron Letters, 1995 , vol. 36, # 50 p. 9085 - 9088
