反应条件
1: 72 percent / Et3N; 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide; 1-hydroxybenzotriazole / CH2Cl2 / 0 - 20 °C
2: 86 percent / NaBr; 4-acetamido-2,2,6,6-tetramethylpiperidine-1-yloxyl; NaOCl / NaHCO3 / toluene; ethyl acetate; H2O / 1.25 h / -5 - 0 °C
View Scheme
参考文献
Yaksh, Tony L.; Kokotos, George; Svensson, Camilla I.; Stephens, Daren; Kokotos, Christoforos G.; Fitzsimmons, Bethany; Hadjipavlou-Litina, Dimitra; Hua, Xiao-Ying; Dennis, Edward A.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 316, # 1 p. 466 - 475
