2-(吡咯烷-2-基)-1H-苯并咪唑合成路线 （共 6 条）
反应条件
hydrogenchloride in water T=130°C; Inert atmosphere;
参考文献
Xu, Hao; Tian, Hua; Liu, Qingwen; Wang, Li; Zhang, Suoqin; Zheng, Liangyu
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 5 p. 1108 - 1113,6
反应条件
hydrogen; palladium on activated charcoal in methanol Hydrogenolysis; P=760 Torr; 2 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 35, # 2 p. 257 - 266
反应条件
1: 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH2Cl2; tetrahydrofuran / 4 h 2: 397 mg / AcOH / 1.5 h / 65 °C 3: H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 35, # 2 p. 257 - 266
反应条件
1: 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH2Cl2; tetrahydrofuran / 4 h 2: 397 mg / AcOH / 1.5 h / 65 °C 3: H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 35, # 2 p. 257 - 266
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 24 p. 6568 - 6572
反应条件
1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0 - 20 °C 1.2: 12 h / 65 °C 2.1: palladium(II) oxide hydrate; hydrogen / methanol / 20 °C / 760.05 Torr View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 52 p. 13159 - 13162
Angew. Chem., , vol. 124, # 52 p. 13336 - 13339,4
