乙基(2E)-3-(3-吡啶基)丙烯酸酯合成路线 （共 37 条）
反应条件
lithium hydroxide in 1,4-dioxane 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 3 p. 320 - 330
反应条件
diisobutylaluminium hydride in diethyl ether; Petroleum ether T=20°C; 20 h;
参考文献
Welter, Carolin; Moreno, Rosa M.; Streiff, Stephane; Helmchen, Guenter
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 18 p. 3266 - 3268
反应条件
1: H2 / 5percent Pd/C / ethanol / 45 °C
2: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
3: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
hydrogen; Rh/Al2O3 in ethanol
T=60°C; P=3102.9 Torr; 12 h;
参考文献
Zarrinmayeh, Hamideh; Nunes, Anne M.; Ornstein, Paul L.; Zimmerman, Dennis M.; Arnold, M. Brian; Schober, Douglas A.; Gackenheimer, Susan L.; Bruns, Robert F.; Hipskind, Philip A.; Britton, Thomas C.; Cantrell, Buddy E.; Gehlert, Donald R.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2709 - 2719
反应条件
1: H2 / 5percent Pd/C / ethanol / 45 °C
2: sodium wire / diethyl ether / 18 h / Ambient temperature
3: ethanol / 7 h / Heating
4: 44 percent / NaOH / H2O; ethanol / 60 °C
5: 69 percent / 2.) ethanolic hydrogen chloride / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Weller, Dwight D.; Stirchak, Eugene P.; Weller, Doreen L.
Journal of Organic Chemistry, 1983 , vol. 48, # 24 p. 4597 - 4605
反应条件
1: H2 / 5percent Pd/C / ethanol / 45 °C
2: sodium wire / diethyl ether / 18 h / Ambient temperature
3: ethanol / 7 h / Heating
4: 44 percent / NaOH / H2O; ethanol / 60 °C
5: 58 percent / 2.) 2 N HBr / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
