trifluoromethylsulfonic anhydride; triethylamine; triphenyl-phosphine oxide in 1,2-dichloro-ethane T=85°C; 2 h; Inert atmosphere;

palladium 10 on activated carbon; oxygen; tetra-(n-butyl)ammonium iodide in 1,4-dioxane T=80°C; P=760.051 Torr; 8 h; Autoclave;

tetraethylammonium chloride; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=50°C; 3 h;

AgCl; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=20°C; 12 h;

bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; hexane T=50°C; 2 h;

1: pyridine-3-aldehyde With TMSC(Li)N2 in tetrahydrofuran; hexane T=-78 - 20°C; 1.5 h; 2: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 3: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran; hexane T=-78°C; 0.5 h; Further stages.;

1: Et3N / (PPh3)2PdCl2, CuI / 4 h / Ambient temperature 2: p-toluenesulfonic acid / benzene / 12 h / Ambient temperature View Scheme

1: Et3N / (PPh3)2PdCl2, CuI / 4 h / Ambient temperature 2: p-toluenesulfonic acid / benzene / 12 h / Ambient temperature View Scheme

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / Reflux 2.1: triethylamine; magnesium chloride / acetonitrile / 2 h / Cooling with ice-salt bath 2.2: 20 °C / Cooling with ice-salt bath 2.3: 1.5 h / Cooling with ice 3.1: trifluoromethylsulfonic anhydride; triethylamine; triphenyl-phosphine oxide / 1,2-dichloro-ethane / 2 h / 85 °C / Inert atmosphere View Scheme

1.1: triethylamine; magnesium chloride / acetonitrile / 2 h / Cooling with ice-salt bath 1.2: 20 °C / Cooling with ice-salt bath 1.3: 1.5 h / Cooling with ice 2.1: trifluoromethylsulfonic anhydride; triethylamine; triphenyl-phosphine oxide / 1,2-dichloro-ethane / 2 h / 85 °C / Inert atmosphere View Scheme