反应条件
1: 1,3-dimethylxanthine With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.166667 h;
2: 1-bromo-4-chloro-butane in N,N-dimethyl-formamide
T=20°C; 24 h; Further stages.;
参考文献
Kim, Soon-Ai; Marshall, Melissa A.; Melman, Neli; Kim, Hak Sung; Mueller, Christa E.; Linden, Joel; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2131 - 2138
