4-(羟基甲基)吡啶甲酸乙酯合成路线 （共 6 条）
反应条件
1: With chloro-trimethyl-silane
T=50°C; 12 h;
2: With water; sodium carbonate
参考文献
SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1602647 A1, 2005 ;
Location in patent: Page/Page column 53 ;
反应条件
1: 87 percent / imidazole / CH2Cl2; dimethylformamide / 3 h
2: 94 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 20 h / Ambient temperature
3: 83 percent / Et3N / 3 h / 90 °C
4: 2.) 6 N aq. HCl / 1.) EtOH, RT,, 20 h, 2.) EtOH, RT, 20 h
View Scheme
参考文献
El Hadri; Leclerc
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 631 - 635
反应条件
1: 94 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 20 h / Ambient temperature
2: 83 percent / Et3N / 3 h / 90 °C
3: 2.) 6 N aq. HCl / 1.) EtOH, RT,, 20 h, 2.) EtOH, RT, 20 h
View Scheme
参考文献
El Hadri; Leclerc
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 631 - 635
反应条件
1: 83 percent / Et3N / 3 h / 90 °C
2: 2.) 6 N aq. HCl / 1.) EtOH, RT,, 20 h, 2.) EtOH, RT, 20 h
View Scheme
参考文献
El Hadri; Leclerc
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 631 - 635
反应条件
hydrogenchloride; sodium
1) 20 h, r.t., 2) 20 h, r.t.; Yield given. Multistep reaction;
参考文献
Hutchison; Williams; Angst; De Jesus; Blanchard; Jackson; Wilusz; Murphy; Bernard; Schneider; Campbell; Guida; Sills
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2171 - 2178
反应条件
hydrogenchloride
1.) EtOH, RT,, 20 h, 2.) EtOH, RT, 20 h; Yield given. Multistep reaction;
参考文献
El Hadri; Leclerc
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 631 - 635
