(R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵合成路线 （共 3 条）
反应条件
in toluene
T=135 - 140°C; Grignard reaction; P=3 Torr;
参考文献
Hull, Jonathan D.; Scheinmann, Feodor; Turner, Nicholas J.
Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 567 - 576
反应条件
in water; acetonitrile
pH=7.1; Resolution of racemate;
参考文献
Somberg, John Charin; Ranade, Vasant V.
Patent: US2010/10096 A1, 2010 ;
Location in patent: Page/Page column 1 ;
反应条件
1: 32 percent / aq. NaOH; dibenzo-18-crown-6 / dimethylsulfoxide / 1 h / 45 - 50 °C
2: 43 percent / toluene / 135 - 140 °C / 3 Torr
View Scheme
参考文献
Hull, Jonathan D.; Scheinmann, Feodor; Turner, Nicholas J.
Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 567 - 576
